Genetic architecture and biology of youth-onset type 2 diabetes.

ABSTRACT: The prevalence of youth-onset type 2 diabetes (T2D) and childhood obesity has been rising steadily¹, producing a growing public health concern¹ that disproportionately affects minority groups². The genetic basis of youth-onset T2D and its relationship to other forms of diabetes are unclear³. Here we report a detailed genetic characterization of youth-onset T2D by analysing exome sequences and common variant associations for 3,005 individuals with youth-onset T2D and 9,777 adult control participants matched for ancestry, including both males and females. We identify monogenic diabetes variants in 2.4% of individuals and three exome-wide significant (P < 2.6 × 10^-6) gene-level associations (HNF1A, MC4R, ATXN2L). Furthermore, we report ra

SUBMITTER: Kwak SH 

PROVIDER: S-EPMC10896722 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature