10-year mortality, causes of death and cardiovascular comorbidities in idiopathic normal pressure hydrocephalus.

ABSTRACT:

Objective

The objective was to investigate 10-year mortality, causes of death and cardiovascular comorbidity in idiopathic normal pressure hydrocephalus (iNPH) and to evaluate their mutual associations.

Methods

This prospective cohort study included 176 CSF-shunted iNPH patients, and 368 age- and sex-matched controls. At inclusion, participants were medically examined, had blood analyzed and answered a questionnaire. The vascular comorbidities investigated were smoking, diabetes, body mass index, blood pressure (BP), hyperlipidemia, kidney function, atrial fibrillation and, cerebro- and cardiovascular disease.

Results

Survival was observed for a mean period of 10.3 ± 0.84 years. Shunted iNPH patients had an increased risk of death compared to controls (hazard ratio (H

SUBMITTER: Eklund SA 

PROVIDER: S-EPMC10896765 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature