Associations of the placental metabolome with immune maturation up to one year of age in the Swedish NICE-cohort.

ABSTRACT:

Introduction

Allergies and other immune-mediated diseases are thought to result from incomplete maturation of the immune system early in life. We previously showed that infants' metabolites at birth were associated with immune cell subtypes during infancy. The placenta supplies the fetus with nutrients, but may also provide immune maturation signals.

Objectives

To examine the relationship between metabolites in placental villous tissue and immune maturation during the first year of life and infant and maternal characteristics (gestational length, birth weight, sex, parity, maternal age, and BMI).

Methods

Untargeted metabolomics was measured using Liquid Chromatography-Mass Spectrometry. Subpopulations of T and B cells were measured using flow cytometry at birth, 48 h,

SUBMITTER: Hartvigsson O 

PROVIDER: S-EPMC10896773 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature