Characterization and immunological effect of outer membrane vesicles from Pasteurella multocida on macrophages.

ABSTRACT: Pasteurella multocida is an important bacterial pathogen that can cause diseases in both animals and humans. Its elevated morbidity and mortality rates in animals result in substantial economic repercussions within the livestock industry. The prevention of diseases caused by P. multocida through immunization is impeded by the absence of a safe and effective vaccine. Outer membrane vesicles (OMVs) secreted from the outer membrane of Gram-negative bacteria are spherical vesicular structures that encompass an array of periplasmic components in conjunction with a diverse assortment of lipids and proteins. These vesicles can induce antibacterial immune responses within the host. P. multocida has been shown to produce OMVs. Nonetheless, the precise characteristics and immunomodulatory functions

SUBMITTER: Sun J 

PROVIDER: S-EPMC10896778 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature