Macro- and micro-structural insights into primary dystonia: a UK Biobank study.

ABSTRACT:

Background

Dystonia is a hyperkinetic movement disorder with key motor network dysfunction implicated in pathophysiology. The UK Biobank encompasses > 500,000 participants, of whom 42,565 underwent brain MRI scanning. This study applied an optimized pre-processing pipeline, aimed at better accounting for artifact and improving data reliability, to assess for grey and white matter structural MRI changes between individuals diagnosed with primary dystonia and an unaffected control cohort.

Methods

Individuals with dystonia (n = 76) were identified from the UK Biobank using published algorithms, alongside an age- and sex-matched unaffected control cohort (n = 311). Grey matter morphometric and diffusion measures were assessed, together with white matter diffusion tensor and diff

SUBMITTER: MacIver CL 

PROVIDER: S-EPMC10896800 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature