The impact of VPS35 D620N mutation on alternative autophagy and its reversal by estrogen in Parkinson's disease.

ABSTRACT: VPS35 plays a key role in neurodegenerative processes in Alzheimer's disease and Parkinson's disease (PD). Many genetic studies have shown a close relationship between autophagy and PD pathophysiology, and specifically, the PD-causing D620N mutation in VPS35 has been shown to impair autophagy. However, the molecular mechanisms underlying neuronal cell death and impaired autophagy in PD are debated. Notably, increasing evidence suggests that Rab9-dependent "alternative" autophagy, which is driven by a different molecular mechanism that driving ATG5-dependent "conventional" autophagy, also contributes to neurodegenerative process. In this study, we investigated the relationship between alternative autophagy and VPS35 D620N mutant-related PD pathogenesis. We isolated iPSCs from the blood mono

SUBMITTER: Shiraishi T 

PROVIDER: S-EPMC10896810 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature