Polygenic risk score predicts all-cause death in East Asian patients with prior coronary artery disease.

ABSTRACT:

Introduction

Coronary artery disease (CAD) is a highly heritable and multifactorial disease. Numerous genome-wide association studies (GWAS) facilitated the construction of polygenic risk scores (PRS) for predicting future incidence of CAD, however, exclusively in European populations. Furthermore, identifying CAD patients with elevated risks of all-cause death presents a critical challenge in secondary prevention, which will contribute largely to reducing the burden for public healthcare.

Methods

We recruited a cohort of 1,776 Chinese CAD patients and performed medical follow-up for up to 11 years. A pruning and thresholding method was used to calculate PRS of CAD and its 14 risk factors. Their correlations with all-cause death were computed via Cox regression.

Results a

SUBMITTER: Qin M 

PROVIDER: S-EPMC10896892 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature