Apoptosis signal-regulating kinase 1 (Ask1) deficiency alleviates MPP⁺-induced impairment of evoked dopamine release in the mouse hippocampus.

ABSTRACT: The dopaminergic system is susceptible to dysfunction in numerous neurological diseases, including Parkinson's disease (PD). In addition to motor symptoms, some PD patients may experience non-motor symptoms, including cognitive and memory deficits. A possible explanation for their manifestation is a disturbed pattern of dopamine release in brain regions involved in learning and memory, such as the hippocampus. Therefore, investigating neuropathological alterations in dopamine release prior to neurodegeneration is imperative. This study aimed to characterize evoked hippocampal dopamine release and assess the impact of the neurotoxin MPP⁺ using a genetically encoded dopamine sensor and gene expression analysis. Additionally, considering the potential neuroprotective attributes dem

SUBMITTER: Zhao F 

PROVIDER: S-EPMC10896914 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature