Urinary Marker Profiles in Heart Failure with Reduced Versus Preserved Ejection Fraction.

ABSTRACT:

Background

Recent data suggest different causes of renal dysfunction between heart failure with reduced (HFrEF) versus preserved ejection fraction (HFpEF). We therefore studied a wide range of urinary markers reflecting different nephron segments in heart failure patients.

Methods

In 2070, in chronic heart failure patients, we measured several established and upcoming urinary markers reflecting different nephron segments.

Results

Mean age was 70 ± 12 years, 74% was male and 81% (n = 1677) had HFrEF. Mean estimated glomerular filtration rate (eGFR) was lower in patients with HFpEF (56 ± 23 versus 63 ± 23 ml/min/1.73 m², P = 0.001). Patients with HFpEF had significantly higher values of NGAL (58.1 [24.0-124.8] versus 28.1 [14.6-66.9] μg/gCr, P < 0.001) and KI

SUBMITTER: Streng KW 

PROVIDER: S-EPMC10896953 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature