Guillain-Barre syndrome and COVID-19 vaccination: a systematic review and meta-analysis.

ABSTRACT:

Background

Case-reports/series and cohorts of Guillain-Barré syndrome (GBS) associated with COVID-19 vaccination have been reported.

Methods

A systematic review and meta-analysis of cohort studies of GBS after COVID-19 vaccination was carried out. Incidence and incidence rate ratio for a number of vaccine doses and risk of GBS, also considering the specific vaccine technology, were calculated in a random-effects model.

Results

Of 554 citations retrieved, 518 were discarded as irrelevant. We finally included 15 studies. The random effect model yielded, regardless of the vaccine technology, 1.25 (95%CI 0.21; 2.83) GBS cases per million of COVID-19 vaccine doses, 3.93 (2.54; 5.54) cases per million doses for adenovirus-vectored vaccines and 0.69 (0.38; 1.06) cases per mi

SUBMITTER: Censi S 

PROVIDER: S-EPMC10896967 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature