Discovery of a novel cytokine signature for the diagnosis of autism spectrum disorder in young Arab children in Qatar.

ABSTRACT:

Background

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder characterized by impaired social interaction and communication and the occurrence of stereotyped and repetitive behaviors. Several studies have reported altered cytokine profiles in ASD and hence may serve as potential diagnostic biomarkers of the disorder. This study aims to identify diagnostic biomarkers for ASD in a well-defined study cohort in Qatar.

Methods

We measured the protein levels of 45 cytokines in the plasma samples of age- and gender-matched children (2-4 years) with ASD (n = 100) and controls (n = 60) using a Luminex multiplex assay. We compared the differences in the levels of these cytokines between the two study groups and then fitted the significantly altered cytokine

SUBMITTER: Nour-Eldine W 

PROVIDER: S-EPMC10896998 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature