Exploring global and local processes underlying alterations in resting-state functional connectivity and dynamics in schizophrenia.

ABSTRACT:

Introduction

We examined changes in large-scale functional connectivity and temporal dynamics and their underlying mechanisms in schizophrenia (ScZ) through measurements of resting-state functional magnetic resonance imaging (rs-fMRI) data and computational modelling.

Methods

The rs-fMRI measurements from patients with chronic ScZ (n=38) and matched healthy controls (n=43), were obtained through the public schizConnect repository. Computational models were constructed based on diffusion-weighted MRI scans and fit to the experimental rs-fMRI data.

Results

We found decreased large-scale functional connectivity across sensory and association areas and for all functional subnetworks for the ScZ group. Additionally global synchrony was reduced in patients while metastabili

SUBMITTER: Metzner C 

PROVIDER: S-EPMC10897003 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature