Impact of 30-day prescribed opioid dose trajectory on fatal overdose risk: A population-based, statewide cohort study.

ABSTRACT:

Background

Both increases and decreases in patients' prescribed daily opioid dose have been linked to increased overdose risk, but associations between 30-day dose trajectories and subsequent overdose risk have not been systematically examined.

Objective

To examine the associations between 30-day prescribed opioid dose trajectories and fatal opioid overdose risk during the subsequent 15 days.

Design

Statewide cohort study using linked prescription drug monitoring program and death certificate data. We constructed a multivariable Cox proportional hazards model that accounted for time-varying prescription-, prescriber-, and pharmacy-level factors.

Participants

All patients prescribed an opioid analgesic in California from March to December, 2013 (5,326,392 patien

SUBMITTER: Henry SG 

PROVIDER: S-EPMC10897080 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature