Association between homocysteine and coronary artery disease-trend over time and across the regions: a systematic review and meta-analysis.

ABSTRACT:

Background

The association of homocysteine with coronary artery disease (CAD) has been explored previously with mixed findings. The present Systematic Review and Meta-Analysis (SRMA) has assessed the pooled estimate of association between homocysteine (Hcy) and CAD, and its variation over the period and geography.

Methods

Systematic literature search was done in PubMed, Scopus and Cochrane to identify the observational studies that have reported mean Hcy among cases (CAD) and control. The SRMA was registered in PROSPERO (ID-CRD42023387675).

Results

Pooled standardized mean difference (SMD) of Hcy levels between the cases and controls was 0.73 (95% CI 0.55-0.91) from 59 studies. Heterogeneity was high (I² 94%). The highest SMD was found among the Asian studi

SUBMITTER: Unadkat SV 

PROVIDER: S-EPMC10897093 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature