Morin improves learning and memory in healthy adult mice.

ABSTRACT:

Background

Morin is a flavonoid found in many edible fruits. The hippocampus and entorhinal cortex play crucial roles in memory formation and consolidation. This study aimed to characterize the effect of morin on recognition and space memory in healthy C57BL/6 adult mice and explore the underlying molecular mechanism.

Methods

Morin was administered i.p. at 1, 2.5, and 5 mg/kg/24 h for 10 days. The Morris water maze (MWM), novel object recognition, novel context recognition, and tasks were conducted 1 day after the last administration. The mice's brains underwent histological characterization, and their protein expression was examined using immunohistochemistry and Western blot techniques.

Results

In the MWM and novel object recognition tests, mice treated with 1 mg/kg

SUBMITTER: Martinez-Coria H 

PROVIDER: S-EPMC10897355 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature