Whole-exome sequencing in UK Biobank reveals rare genetic architecture for depression.

ABSTRACT: Nearly two hundred common-variant depression risk loci have been identified by genome-wide association studies (GWAS). However, the impact of rare coding variants on depression remains poorly understood. Here, we present whole-exome sequencing analyses of depression with seven different definitions based on survey, questionnaire, and electronic health records in 320,356 UK Biobank participants. We showed that the burden of rare damaging coding variants in loss-of-function intolerant genes is significantly associated with risk of depression with various definitions. We compared the rare and common genetic architecture across depression definitions by genetic correlation and showed different genetic relationships between definitions across common and rare variants. In addition, we demonstrat

SUBMITTER: Tian R 

PROVIDER: S-EPMC10897433 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature