Transcriptomic effects of paternal cocaine-seeking on the reward circuitry of male offspring.

ABSTRACT: It has been previously established that paternal development of a strong incentive motivation for cocaine can predispose offspring to develop high cocaine-seeking behavior, as opposed to sole exposure to the drug that results in drug resistance in offspring. However, the adaptive changes of the reward circuitry have not been fully elucidated. To infer the key nuclei and possible hub genes that determine susceptibility to addiction in offspring, rats were randomly assigned to three groups, cocaine self-administration (CSA), yoked administration (Yoke), and saline self-administration (SSA), and used to generate F1. We conducted a comprehensive transcriptomic analysis of the male F1 offspring across seven relevant brain regions, both under drug-naïve conditions and after cocaine self-administ

SUBMITTER: Huang N 

PROVIDER: S-EPMC10897445 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature