Ontology highlight
ABSTRACT:
SUBMITTER: Bao X
PROVIDER: S-EPMC10897549 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Bao Xuanwen X Li Qiong Q Chen Dong D Dai Xiaomeng X Liu Chuan C Tian Weihong W Zhang Hangyu H Jin Yuzhi Y Wang Yin Y Cheng Jinlin J Lai Chunyu C Ye Chanqi C Xin Shan S Li Xin X Su Ge G Ding Yongfeng Y Xiong Yangyang Y Xie Jindong J Tano Vincent V Wang Yanfang Y Fu Wenguang W Deng Shuiguang S Fang Weijia W Sheng Jianpeng J Ruan Jian J Zhao Peng P
Cell reports. Medicine 20240201 2
Colorectal cancer (CRC) is a common malignancy involving multiple cellular components. The CRC tumor microenvironment (TME) has been characterized well at single-cell resolution. However, a spatial interaction map of the CRC TME is still elusive. Here, we integrate multiomics analyses and establish a spatial interaction map to improve the prognosis, prediction, and therapeutic development for CRC. We construct a CRC immune module (CCIM) that comprises FOLR2<sup>+</sup> macrophages, exhausted CD8 ...[more]