Ontology highlight
ABSTRACT:
SUBMITTER: Fondevila MF
PROVIDER: S-EPMC10897550 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Fondevila Marcos F MF Novoa Eva E Gonzalez-Rellan Maria J MJ Fernandez Uxia U Heras Violeta V Porteiro Begoña B Parracho Tamara T Dorta Valentina V Riobello Cristina C da Silva Lima Natalia N Seoane Samuel S Garcia-Vence Maria M Chantada-Vazquez Maria P MP Bravo Susana B SB Senra Ana A Leiva Magdalena M Marcos Miguel M Sabio Guadalupe G Perez-Fernandez Roman R Dieguez Carlos C Prevot Vincent V Schwaninger Markus M Woodhoo Ashwin A Martinez-Chantar Maria L ML Schwabe Robert R Cubero Francisco J FJ Varela-Rey Marta M Crespo Javier J Iruzubieta Paula P Nogueiras Ruben R
Cell reports. Medicine 20240209 2
The p63 protein has pleiotropic functions and, in the liver, participates in the progression of nonalcoholic fatty liver disease (NAFLD). However, its functions in hepatic stellate cells (HSCs) have not yet been explored. TAp63 is induced in HSCs from animal models and patients with liver fibrosis and its levels positively correlate with NAFLD activity score and fibrosis stage. In mice, genetic depletion of TAp63 in HSCs reduces the diet-induced liver fibrosis. In vitro silencing of p63 blunts T ...[more]