Cell-specific alterations in autophagy-lysosomal activity near the chronically implanted microelectrodes.

ABSTRACT: Intracortical microelectrodes that can record and stimulate brain activity have become a valuable technique for basic science research and clinical applications. However, long-term implantation of these microelectrodes can lead to progressive neurodegeneration in the surrounding microenvironment, characterized by elevation in disease-associated markers. Dysregulation of autophagy-lysosomal degradation, a major intracellular waste removal process, is considered a key factor in the onset and progression of neurodegenerative diseases. It is plausible that similar dysfunctions in autophagy-lysosomal degradation contribute to tissue degeneration following implantation-induced focal brain injury, ultimately impacting recording performance. To understand how the focal, persistent brain injury cau

SUBMITTER: Chen K 

PROVIDER: S-EPMC10897938 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature