Using novel data linkage of congenital heart disease biobank data with administrative health data to identify cardiovascular outcomes to inform genomic analysis.

ABSTRACT:

Introduction

Contemporary care of congenital heart disease (CHD) is largely standardised, however there is heterogeneity in post-surgical outcomes that may be explained by genetic variation. Data linkage between a CHD biobank and routinely collected administrative datasets is a novel method to identify outcomes to explore the impact of genetic variation.

Objective

Use data linkage to identify and validate patient outcomes following surgical treatment for CHD.

Methods

Data linkage between clinical and biobank data of children born from 2001-2014 that had a procedure for CHD in New South Wales, Australia, with hospital discharge data, education and death data. The children were grouped according to CHD lesion type and age at first cardiac surgery. Children in each 'lesi

SUBMITTER: Lain SJ 

PROVIDER: S-EPMC10897946 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature