Trait- and state-like co-activation pattern dynamics in current and remitted major depressive disorder.

ABSTRACT:

Background

Distinguishing between trait- and state-like neural alternations in major depressive disorder (MDD) may advance our understanding of this recurring disorder. We aimed to investigate dynamic functional connectivity alternations in unmedicated individuals with current or past MDD using co-activation pattern analyses.

Methods

Resting-state functional magnetic resonance imaging data were acquired from individuals with first-episode current MDD (cMDD, n = 50), remitted MDD (rMDD, n = 44), and healthy controls (HCs, n = 64). Using a data-driven consensus clustering technique, four whole-brain states of spatial co-activation were identified and associated metrics (dominance, entries, transition frequency) were analyzed with respect to clinical characteristics.

Results

SUBMITTER: Liu C 

PROVIDER: S-EPMC10897955 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature