Identification of enterotype and its predictive value for patients with colorectal cancer.

ABSTRACT:

Background

Gut microbiota dysbiosis involved in the pathogenesis of colorectal cancer (CRC). The characteristics of enterotypes in CRC development have not been determined.

Objective

To characterize the gut microbiota of healthy, adenoma, and CRC subjects based on enterotype.

Methods

The 16 S rRNA sequencing data from 315 newly sequenced individuals and three previously published datasets were collected, providing total data for 367 healthy, 320 adenomas, and 415 CRC subjects. Enterotypes were analyzed for all samples, and differences in microbiota composition across subjects with different disease states in each enterotype were determined. The predictive values of a random forest classifier based on enterotype in distinguishing healthy, adenoma, and CRC subjects were

SUBMITTER: Qingbo L 

PROVIDER: S-EPMC10897996 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature