Identification of common stria vascularis cellular alteration in sensorineural hearing loss based on ScRNA-seq.

ABSTRACT:

Background

The stria vascularis (SV), located in the lateral wall of the cochlea, maintains cochlear fluid homeostasis and mechanoelectrical transduction (MET) activity required for sound wave conduction. The pathogenesis of a number of human inheritable deafness syndromes, age related hearing loss, drug-induced ototoxicity and noise-induced hearing loss results from the morphological changes and functional impairments in the development of the SV. In this study, we investigate the implications of intercellular communication within the SV in the pathogenesis of sensorineural hearing loss (SNHL). We aim to identify commonly regulated signaling pathways using publicly available single-cell transcriptomic sequencing (scRNA-seq) datasets.

Methods

We analyzed scRNA-seq data, whic

SUBMITTER: Gu X 

PROVIDER: S-EPMC10897997 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature