Influence of a chronic beta-blocker therapy on perioperative opioid consumption - a post hoc secondary analysis.

ABSTRACT:

Background

Beta-blocker (BB) therapy plays a central role in the treatment of cardiovascular diseases. An increasing number of patients with cardiovascular diseases undergoe noncardiac surgery, where opioids are an integral part of the anesthesiological management. There is evidence to suggest that short-term intravenous BB therapy may influence perioperative opioid requirements due to an assumed cross-talk between G-protein coupled beta-adrenergic and opioid receptors. Whether chronic BB therapy could also have an influence on perioperative opioid requirements is unclear.

Methods

A post hoc analysis of prospectively collected data from a multicenter observational (BioCog) study was performed. Inclusion criteria consisted of elderly patients (≥ 65 years) undergoing elective

SUBMITTER: Trauzeddel RF 

PROVIDER: S-EPMC10898005 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature