Polygenic effects on the risk of Alzheimer's disease in the Japanese population.

ABSTRACT:

Background

Polygenic effects have been proposed to account for some disease phenotypes; these effects are calculated as a polygenic risk score (PRS). This score is correlated with Alzheimer's disease (AD)-related phenotypes, such as biomarker abnormalities and brain atrophy, and is associated with conversion from mild cognitive impairment (MCI) to AD. However, the AD PRS has been examined mainly in Europeans, and owing to differences in genetic structure and lifestyle, it is unclear whether the same relationships between the PRS and AD-related phenotypes exist in non-European populations. In this study, we calculated and evaluated the AD PRS in Japanese individuals using genome-wide association study (GWAS) statistics from Europeans.

Methods

In this study, we calculated the

SUBMITTER: Kikuchi M 

PROVIDER: S-EPMC10898021 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature