CircRNA identification and feature interpretability analysis.

ABSTRACT:

Background

Circular RNAs (circRNAs) can regulate microRNA activity and are related to various diseases, such as cancer. Functional research on circRNAs is the focus of scientific research. Accurate identification of circRNAs is important for gaining insight into their functions. Although several circRNA prediction models have been developed, their prediction accuracy is still unsatisfactory. Therefore, providing a more accurate computational framework to predict circRNAs and analyse their looping characteristics is crucial for systematic annotation.

Results

We developed a novel framework, CircDC, for classifying circRNAs from other lncRNAs. CircDC uses four different feature encoding schemes and adopts a multilayer convolutional neural network and bidirectional long short-te

SUBMITTER: Niu M 

PROVIDER: S-EPMC10898045 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature