Distinct uric acid trajectories are associated with incident cardiac conduction block.

ABSTRACT:

Background

The association of longitudinal uric acid (UA) changes with cardiac conduction block risk is unclear. We aimed to identify the trajectories of UA and explore its association with cardiac conduction block.

Methods

A total of 67,095 participants with a mean age of 53.12 years were included from the Kailuan cohort in Tangshan, China, who were free of cardiac conduction block and with repeated measurements of UA from 2006 to 2012. UA trajectories during 2006 to 2012 were identified by group-based trajectory modeling. Cox proportional hazard regression models were used to assess the association of UA trajectories with cardiac conduction block.

Results

We categorized three observed discrete trajectories of UA during 2006-2012 period: low-stable, moderate-stable,

SUBMITTER: Li N 

PROVIDER: S-EPMC10898057 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature