Assessing the causal relationship between 731 immunophenotypes and the risk of lung cancer: a bidirectional mendelian randomization study.

ABSTRACT:

Background

Previous studies have observed a link between immunophenotypes and lung cancer, both of which are closely associated with genetic factors. However, the causal relationship between them remains unclear.

Methods

Bidirectional Mendelian randomization (MR) was performed on publicly available genome-wide association study (GWAS) summary statistics to analyze the causal relationships between 731 immunophenotypes and lung cancer. Sensitivity analyses were conducted to verify the robustness, heterogeneity, and potential horizontal pleiotropy of our findings.

Results

Following Bonferroni adjustment, CD14^- CD16⁺ monocyte (OR = 0.930, 95%CI 0.900-0.960, P = 8.648 × 10^- 6, P_Bonferroni = 0.006) and CD27 on CD24⁺ CD2

SUBMITTER: Xu M 

PROVIDER: S-EPMC10898084 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature