Microbial composition, functionality, and stress resilience or susceptibility: unraveling sex-specific patterns.

ABSTRACT:

Background

Following exposure to traumatic stress, women are twice as likely as men to develop mood disorders. Yet, individual responses to such stress vary, with some people developing stress-induced psychopathologies while others exhibit resilience. The factors influencing sex-related disparities in affective disorders as well as variations in resilience remain unclear; however, emerging evidence suggests differences in the gut microbiota play a role. In this study, using the single prolonged stress (SPS) model of post-traumatic stress disorder, we investigated pre- and post-existing differences in microbial composition, functionality, and metabolites that affect stress susceptibility or resilience in each sex.

Methods

Male and female Sprague-Dawley rats were randomly assi

SUBMITTER: Tanelian A 

PROVIDER: S-EPMC10898170 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature