Potency, immunogenicity, and efficacy of rabies vaccine: In vitro and in vivo approach.

ABSTRACT:

Background

Rabies, a potentially lethal virus, affects more than 150 countries. Although the rabies vaccine and immunoglobulin have been available since 1908, Bangladesh is new to vaccine manufacturing. We checked the quality of the local manufacturing rabies vaccine for substandard.

Methods

The potency and immunogenicity of 20 vaccines were analyzed by three in vivo and in vitro methods from March 2020 to May 2023. Single radial immunodiffusion, fluorescent antibody virus neutralization, and national institutes of health tests were carried out to evaluate the vaccine's efficacy to provide sufficient protection against the rabies virus.

Results

The potency of the rabies vaccine was determined by the in vitro SRID method by measuring glycoprotein content. An average of

SUBMITTER: Akter F 

PROVIDER: S-EPMC10898210 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature