Role of alveolar nitric oxide in gastroesophageal reflux-associated cough: prospective observational study.

ABSTRACT:

Background

Fractional exhaled nitric oxide (FeNO) measured at multiple exhalation flow rates can be used as a biomarker to differentiate central and peripheral airway inflammation. However, the role of alveolar nitric oxide (CaNO) indicating peripheral airway inflammation remains unclear in gastroesophageal reflux-associated cough (GERC).

Objectives

We aimed to characterize the changes in alveolar nitric oxide (CaNO) and determine its clinical implication in GERC.

Design

This is a single-center prospective observational study.

Methods

FeNOs at exhalation flow rates of 50 and 200 ml/s were measured in 102 patients with GERC and 134 patients with other causes of chronic cough (non-GERC). CaNO was calculated based on a two-compartment model and the factors associa

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10898302 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature