Validation of serum cystatin SN detection for diagnosis and poor prognosis of esophageal squamous cell carcinoma.

ABSTRACT:

Background

The identification of effective tumor markers is of paramount importance for the early diagnosis, treatment, and prognosis of esophageal squamous cell carcinoma (ESCC). The present study endeavors to identify efficacious serological markers that can differentiate patients with early-stage ESCC from those with benign esophageal lesions and healthy controls (HC). Cystatin-SN (CST1), an active cysteine protease inhibitor belonging to the Cystatin (CST) superfamily, is implicated in the pathogenesis of inflammation and tumorigenesis. The objective of this investigation is to assess the diagnostic, therapeutic, and prognostic potential of serum CST1 in ESCC.

Methods

In our prior RNA sequencing and screening endeavors, we have identified ten genes that are up-regulated

SUBMITTER: Pi Y 

PROVIDER: S-EPMC10898351 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature