Severe, life-threatening, and fatal chronic health conditions after allogeneic blood or marrow transplantation in childhood.

ABSTRACT:

Background

A comprehensive assessment of morbidity after allogeneic bone marrow transplantation (BMT) performed in childhood remains understudied.

Methods

Seven hundred eighty-nine allogeneic BMT recipients who had survived ≥2 years after BMT performed between 1974 and 2014 at age <22 years and 690 siblings completed a 255-item survey self-reporting sociodemographics and chronic health conditions. A severity score (grade 3 [severe], 4 [life-threatening], or 5 [fatal]) was assigned to the conditions using Common Terminology Criteria for Adverse Events, version 5.0. For the BMT cohort, the cumulative incidence of chronic health conditions was calculated as a function of time from BMT. Proportional subdistribution hazards models were used to determine predictors of grade 3-5 co

SUBMITTER: Holmqvist AS 

PROVIDER: S-EPMC10898430 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature