Endolysosomal trafficking controls yolk granule biogenesis in vitellogenic Drosophila oocytes.

ABSTRACT: Endocytosis and endolysosomal trafficking are essential for almost all aspects of physiological functions of eukaryotic cells. As our understanding on these membrane trafficking events are mostly from studies in yeast and cultured mammalian cells, one challenge is to systematically evaluate the findings from these cell-based studies in multicellular organisms under physiological settings. One potentially valuable in vivo system to address this challenge is the vitellogenic oocyte in Drosophila, which undergoes extensive endocytosis by Yolkless (Yl), a low-density lipoprotein receptor (LDLR), to uptake extracellular lipoproteins into oocytes and package them into a specialized lysosome, the yolk granule, for storage and usage during later development. However, by now there is still a lack o

SUBMITTER: Yu Y 

PROVIDER: S-EPMC10898735 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature