Osteo-inductive effect of piezoelectric stimulation from the poly(l-lactic acid) scaffolds.

ABSTRACT: Piezoelectric biomaterials can generate piezoelectrical charges in response to mechanical activation. These generated charges can directly stimulate bone regeneration by triggering signaling pathway that is important for regulating osteogenesis of cells seeded on the materials. On the other hand, mechanical forces applied to the biomaterials play an important role in bone regeneration through the process called mechanotransduction. While mechanical force and electrical charges are both important contributing factors to bone tissue regeneration, they operate through different underlying mechanisms. The utilizations of piezoelectric biomaterials have been explored to serve as self-charged scaffolds which can promote stem cell differentiation and the formation of functional bone tissues. Howe

SUBMITTER: Das R 

PROVIDER: S-EPMC10898771 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature