RBPMS regulates cardiomyocyte contraction and cardiac function through RNA alternative splicing.

ABSTRACT:

Aims

RNA binding proteins play essential roles in mediating RNA splicing and are key post-transcriptional regulators in the heart. Our recent study demonstrated that RBPMS (RNA binding protein with multiple splicing) is crucial for cardiac development through modulating mRNA splicing, but little is known about its functions in the adult heart. In this study, we aim to characterize the post-natal cardiac function of Rbpms and its mechanism of action.

Methods and results

We generated a cardiac-specific knockout mouse line and found that cardiac-specific loss of Rbpms caused severe cardiomyocyte contractile defects, leading to dilated cardiomyopathy and early lethality in adult mice. We showed by proximity-dependent biotin identification assay and mass spectrometry that RBPMS a

SUBMITTER: Gan P 

PROVIDER: S-EPMC10898938 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature