Positive Selection Drives cis-regulatory Evolution Across the Threespine Stickleback Y Chromosome.

ABSTRACT: Allele-specific gene expression evolves rapidly on heteromorphic sex chromosomes. Over time, the accumulation of mutations on the Y chromosome leads to widespread loss of gametolog expression, relative to the X chromosome. It remains unclear if expression evolution on degrading Y chromosomes is primarily driven by mutations that accumulate through processes of selective interference, or if positive selection can also favor the down-regulation of coding regions on the Y chromosome that contain deleterious mutations. Identifying the relative rates of cis-regulatory sequence evolution across Y chromosomes has been challenging due to the limited number of reference assemblies. The threespine stickleback (Gasterosteus aculeatus) Y chromosome is an excellent model to identify how regulatory muta

SUBMITTER: Shaw DE 

PROVIDER: S-EPMC10899008 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature