Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease.

ABSTRACT: Metastatic gastric carcinoma is a highly lethal cancer that responds poorly to conventional and molecularly targeted therapies. Despite its clinical relevance, the mechanisms underlying the behavior and therapeutic response of this disease are poorly understood owing, in part, to a paucity of tractable models. Here we developed methods to somatically introduce different oncogenic lesions directly into the murine gastric epithelium. Genotypic configurations observed in patients produced metastatic gastric cancers that recapitulated the histological, molecular and clinical features of all nonviral molecular subtypes of the human disease. Applying this platform to both wild-type and immunodeficient mice revealed previously unappreciated links between the genotype, organotropism and immune sur

SUBMITTER: Leibold J 

PROVIDER: S-EPMC10899107 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature