Eosinophils promote CD8⁺ T cell memory generation to potentiate anti-bacterial immunity.

ABSTRACT: Memory CD8⁺ T cell generation is crucial for pathogen elimination and effective vaccination against infection. The cellular and molecular circuitry that underlies the generation of memory CD8⁺ T cells remains elusive. Eosinophils can modulate inflammatory allergic responses and interact with lymphocytes to regulate their functions in immune defense. Here we report that eosinophils are required for the generation of memory CD8⁺ T cells by inhibiting CD8⁺ T cell apoptosis. Eosinophil-deficient mice display significantly impaired memory CD8⁺ T cell response and weakened resistance against Listeria monocytogenes (L.m.) infection. Mechanistically, eosinophils secrete interleukin-4 (IL-4) to inhibit JNK/Caspase-3 dependent apoptosis of CD8

SUBMITTER: Zhou J 

PROVIDER: S-EPMC10899176 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature