Elevated CD169 expressing monocyte/macrophage promotes systemic inflammation and disease progression in cirrhosis.

ABSTRACT: Systemic inflammation is related to disease progression and prognosis in patients with advanced cirrhosis. However, the mechanisms underlying the initiation of inflammation are still not fully understood. The role of CD169⁺ monocyte/macrophage in cirrhotic systemic inflammation was undetected. Flow cytometry analysis was used to detect the percentage and phenotypes of CD169⁺ monocytes as well as their proinflammatory function in patient-derived cirrhotic tissue and blood. Transcriptome differences between CD169⁺ and CD169^- monocytes were also compared. Additionally, a mouse model with specific depletion of CD169⁺ monocytes/macrophages was utilized to define their role in liver injury and fibrosis. We observed increased CD169 expression

SUBMITTER: Xu L 

PROVIDER: S-EPMC10899294 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature