Impact of alkaline phosphatase on clinical outcomes in patients with ischemic stroke: a nationwide registry analysis.

ABSTRACT:

Background

Data on the association between serum alkaline phosphatase (ALP) levels and clinical outcomes in patients with ischemic stroke (IS) are inconsistent and limited. Therefore, this study aimed to investigate the correlation between ALP and prognosis in patients with IS.

Methods

Patients with acute ischemic stroke (AIS) or transient ischemic attack (TIA) from the Third China National Stroke Registry were divided into four groups according to the quartiles of serum ALP levels on admission. Cox proportional hazards and logistic regression models were used to evaluate the correlation between ALP and the risk of all-cause mortality, disability (modified Rankin Scale (mRS) score 3-5), and poor functional outcomes (mRS score 3-6).

Results

A total of 11,405 patients w

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10899335 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature