Optimal decoding of neural dynamics occurs at mesoscale spatial and temporal resolutions.

ABSTRACT:

Introduction

Understanding the neural code has been one of the central aims of neuroscience research for decades. Spikes are commonly referred to as the units of information transfer, but multi-unit activity (MUA) recordings are routinely analyzed in aggregate forms such as binned spike counts, peri-stimulus time histograms, firing rates, or population codes. Various forms of averaging also occur in the brain, from the spatial averaging of spikes within dendritic trees to their temporal averaging through synaptic dynamics. However, how these forms of averaging are related to each other or to the spatial and temporal units of information representation within the neural code has remained poorly understood.

Materials and methods

In this work we developed NeuroPixelHD, a symbol

SUBMITTER: Samiei T 

PROVIDER: S-EPMC10899419 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature