Patient-reported outcome measures in patients with familial cerebral cavernous malformations: results from the Treat_CCM trial.

ABSTRACT:

Background

The Phase 1/2 Treat_CCM randomized controlled trial for people with familial cerebral cavernous malformations (FCCMs) confirmed the safety of propranolol and suggested beneficial effects on intracerebral hemorrhage or new focal neurological deficits, but the effects on patient-reported outcome measures have not been reported.

Methods

Participants completed self-reported questionnaires at baseline, 1 and 2 years. Depression was assessed with the Beck Depression Inventory-II (BDI-2); Anxiety with the State-Trait Anxiety Inventory X1 and X2 (STAI X-1 and STAI X-2); and Quality of Life with the Short Form 36 (SF-36), split into the physical and mental component scales (PCS and MCS). Differences between treatment groups and the general population were assessed. Change

SUBMITTER: Meessen JMTA 

PROVIDER: S-EPMC10899450 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature