SARS-CoV-2 spike-reactive naive B cells and pre-existing memory B cells contribute to antibody responses in unexposed individuals after vaccination.

ABSTRACT:

Introduction

Since December 2019, the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) has presented considerable public health challenges. Multiple vaccines have been used to induce neutralizing antibodies (nAbs) and memory B-cell responses against the viral spike (S) glycoprotein, and many essential epitopes have been defined. Previous reports have identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike-reactive naïve B cells and preexisting memory B cells in unexposed individuals. However, the role of these spike-reactive B cells in vaccine-induced immunity remains unknown.

Methods

To elucidate the characteristics of preexisting SARS-CoV-2 S-reactive B cells as well as their maturat

SUBMITTER: Teng S 

PROVIDER: S-EPMC10899457 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature