Interferon type I signature associated with skin disease in juvenile dermatomyositis.

ABSTRACT:

Background

Interferon type I (IFN-I) signaling system hyperactivation plays an important role in the pathogenesis of juvenile dermatomyositis (JDM).

Aim of the study

To analyze IFN-I score with disease activity in patients with JDM.

Materials and methods

Clinical manifestations laboratory data, and treatment options were analyzed in 15 children with JDM. Disease activity was assessed by CMAS (childhood myositis assessment tool) and CAT (cutaneous assessment tool) scores. IFN I-score was assessed by RT-PCR quantitation of 5 IFN I-regulated transcripts (IFI44L, IFI44, IFIT3, LY6E, MXA1).

Results

All patients had skin and muscle involvement, some had a fever (n = 8), swallowing disorders (n = 4), arthritis (n = 5), calcinosis (n = 3), l

SUBMITTER: Raupov R 

PROVIDER: S-EPMC10899462 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature