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Kinetics and functional consequences of BK channels activation by N-type Ca²⁺ channels in the dendrite of mouse neocortical layer-5 pyramidal neurons.

ABSTRACT: The back-propagation of an action potential (AP) from the axon/soma to the dendrites plays a central role in dendritic integration. This process involves an intricate orchestration of various ion channels, but a comprehensive understanding of the contribution of each channel type remains elusive. In this study, we leverage ultrafast membrane potential recordings (V_m) and Ca²⁺ imaging techniques to shed light on the involvement of N-type voltage-gated Ca²⁺ channels (VGCCs) in layer-5 neocortical pyramidal neurons' apical dendrites. We found a selective interaction between N-type VGCCs and large-conductance Ca²⁺-activated K⁺ channels (BK CAKCs). Remarkably, we observe that BK CAKCs are activated within a mere 500 μs after the AP p

SUBMITTER: Blomer LA

PROVIDER: S-EPMC10899506 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

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Dataset Information

Kinetics and functional consequences of BK channels activation by N-type Ca²⁺ channels in the dendrite of mouse neocortical layer-5 pyramidal neurons.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Kinetics and functional consequences of BK channels activation by N-type Ca2+ channels in the dendrite of mouse neocortical layer-5 pyramidal neurons.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Kinetics and functional consequences of BK channels activation by N-type Ca²⁺ channels in the dendrite of mouse neocortical layer-5 pyramidal neurons.