Untargeted metabolomic profiling of serum from client-owned cats with early and late-stage chronic kidney disease.

ABSTRACT: Evaluation of the metabolome could discover novel biomarkers of disease. To date, characterization of the serum metabolome of client-owned cats with chronic kidney disease (CKD), which shares numerous pathophysiological similarities to human CKD, has not been reported. CKD is a leading cause of feline morbidity and mortality, which can be lessened with early detection and appropriate treatment. Consequently, there is an urgent need for early-CKD biomarkers. The goal of this cross-sectional, prospective study was to characterize the global, non-targeted serum metabolome of cats with early versus late-stage CKD compared to healthy cats. Analysis revealed distinct separation of the serum metabolome between healthy cats, early-stage and late-stage CKD. Differentially abundant lipid and amino a

SUBMITTER: Nealon NJ 

PROVIDER: S-EPMC10899575 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature