A comparison of the performance of ⁶⁸Ga-Pentixafor PET/CT versus adrenal vein sampling for subtype diagnosis in primary aldosteronism.

ABSTRACT:

Objective

To investigate the diagnostic efficiency and prognostic value of ⁶⁸Ga-Pentixafor PET/CT in comparison with adrenal vein sampling (AVS) for functional lateralization in primary aldosteronism (PA). Histology and long-term clinical follow-up normally serve as the gold standard for such diagnosis.

Methods

We prospectively recruited 26 patients diagnosed with PA. All patients underwent ⁶⁸Ga-Pentixafor PET/CT and AVS. Postsurgical biochemical and clinical outcomes of patients with unilateral primary aldosteronism (UPA), as diagnosed by PET/CT or AVS, were assessed by applying standardized Primary Aldosteronism Surgical Outcome (PASO) criteria. Immunohistochemistry (IHC) was performed to detect the expression of aldosterone synthase (CYP11B2) and CXC

SUBMITTER: Yin X 

PROVIDER: S-EPMC10899670 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature