Genetic and environmental factors driving congenital solitary functioning kidney.

ABSTRACT:

Background

Congenital solitary functioning kidney (CSFK) is an anomaly predisposing to hypertension, albuminuria and chronic kidney disease. Its aetiology is complex and includes genetic and environmental factors. The role of gene-environment interactions (G×E), although relevant for other congenital anomalies, has not yet been investigated. Therefore, we performed a genome-wide G×E analysis with six preselected environmental factors to explore the role of these interactions in the aetiology of CSFK.

Methods

In the AGORA (Aetiologic research into Genetic and Occupational/environmental Risk factors for Anomalies in children) data- and biobank, genome-wide single-nucleotide variant (SNV) data and questionnaire data on prenatal exposure to environmental risk factors were availa

SUBMITTER: Groen In 't Woud S 

PROVIDER: S-EPMC10899751 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature